![]() The Society for Endocrinology has endorsed a joint guidance document written together with Specialist Pharmacy Services.Īdrenal crisis can also occur in patients with known adrenal insufficiency if existing cortisol replacement does not meet the increased need for cortisol, e.g. Patients taking exogenous glucocorticoids across any route (oral, intra-articular, intra-muscular, inhaled, nasal and topical preparations) being used to treat a variety of medical conditions, can cause adrenal insufficiency by suppressing the hypothalamo-pituitary-adrenal axis. injection of 50mg hydrocortisone every 6 hours) until clinical recovery and further guidance by an endocrinologist.Īdrenal crisis can be a manifestation of previously undiagnosed adrenal failure. ![]() Please maintain the patient on hydrocortisone at a dose of 200mg hydrocortisone per 24 hours (preferably by continuous i.v. administration of 0.9% saline solution (or equivalent). Please immediately inject 100mg hydrocortisone i.v. Management of adrenal crisis summary If you suspect established or developing adrenal crisis in a patient Short-term administration of high doses of glucocorticoids is never harmful but failure to treat adrenal crisis can result in the death of the patient. Diagnostic measures should never delay treatment and if adrenal crisis is suspected, treatment should be initiated WITHOUT DELAY.
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